Focal Therapy

Our Publications on Focal Therapy

Blazevski, A., Scheltema, M. J., Amin, A., Thompson, J. E., & Lawrentschuk, N. (2019). Irreversible electroporation (IRE): a narrative review of the development of IRE from the laboratory to a prostate cancer treatment. BJU International. Advance online publication. https://doi.org/10.1111/bju.14951

Blazevski, A., Scheltema, M. J., Amin, A., Thompson, J. E., & Lawrentschuk, N. (2020). Irreversible electroporation (IRE): a narrative review of the development of IRE from the laboratory to a prostate cancer treatment. BJU International, 125(3), 369–378. https://doi.org/10.1111/bju.14951

Blazevski, A., Amin, A., Scheltema, M. J., Balakrishnan, A., Haynes, A. M., Barreto, D., Cusick, T., Thompson, J., & Stricker, P. D. (2021). Focal ablation of apical prostate cancer lesions with irreversible electroporation (IRE). World Journal of Urology, 39(4), 1107–1114. https://doi.org/10.1007/s00345-020-03275-z

Blazevski, A., Geboers, B., Scheltema, M. J., Gondoputro, W., Doan, P., Katelaris, A., Agrawal, S., Baretto, D., Matthews, J., Haynes, A. M., Delprado, W., Shnier, R., Van den Bos, W., Thompson, J. E., Lawrentschuk, N., & Stricker, P. D. (2022). Salvage irreversible electroporation for radio-recurrent prostate cancer - the prospective FIRE trial. BJU International. Advance online publication. https://doi.org/10.1111/bju.15947

Blazevski, A., Gondoputro, W., Scheltema, M. J., Amin, A., Geboers, B., Barreto, D., Haynes, A. M., Shnier, R., Delprado, W., Agrawal, S., Thompson, J. E., & Stricker, P. D. (2022). Salvage robot-assisted radical prostatectomy following focal ablation with irreversible electroporation: feasibility, oncological and functional outcomes. BMC Urology, 22(1), 28. https://doi.org/10.1186/s12894-022-00978-w

Blazevski, A., Scheltema, M. J., Yuen, B., Masand, N., Nguyen, T. V., Delprado, W., Shnier, R., Haynes, A., Cusick, T., Thompson, J., & Stricker, P. (2020). Oncological and quality-of-life outcomes following focal irreversible electroporation as primary treatment for localised prostate cancer: A biopsy-monitored prospective cohort. European Urology Oncology, 3(3), 382–390. https://doi.org/10.1016/j.euo.2019.04.008

Cussenot, O., & Stricker, P. D. (2021). Irreversible electroporation for patients with localised prostate cancer: Expert opinion on this versatile therapeutic approach. EMJ Urology, 9(1), 56–62. https://www.emjreviews.com/urology/article/irreversible-electroporation-for-patients-with-localised-prostate-cancer-expert-opinion-on-this-versatile-therapeutic-approach-j180121

Deivasigamani, S., Kotamarti, S., Rastinehad, A. R., Lebastchi, A. H., Tay, K. J., Polascik, T. J., Zargar, H., Mains, E., Sidana, A., Gorin, M. A., Siddiqui, M. M., Doshi, C., Halpern, J. A., Kinnaird, A., Johnson, B., Yaxley, W. J., Grummet, J., Kasivisvanathan, V., Oto, A., … Eggener, S. E. (2023). Primary whole-gland ablation for the treatment of clinically localized prostate cancer: A Focal Therapy Society Best Practice Statement. European Urology, 84(6), 547–560. https://doi.org/10.1016/j.eururo.2023.06.013

Durazo-Ruiz, F. O., Roldán-Testillano, R., Rodriguez-Sanchez, L., Laguna, M. P., Mendez-Bisgaard, L., Arezki, A., Elkhatib, H., Hevia-Feliu, A., Zhang, K., Fainberg, J., Perlis, N., Rosette, J. J. L., Miñana-López, B., de Reijke, T. M., Anidjar, M., Emberton, M., Stricker, P. D., & Sanchez-Salas, R. (2025). Irreversible electroporation in focal therapy for prostate cancer: Current status and future directions. Prostate International. Advance online publication. https://doi.org/10.1016/j.prnil.2025.11.001

Emberton, M., de Reijke, T., Stricker, P., Miñana, B., Bianco, F., Dominguez Escrig, J. L., Lantz, A., & Sanchez-Salas, R. (2023). Revisiting Delphi to create a basis for the future of focal therapy for prostate cancer. The Journal of Urology. Advance online publication. Urology Journal URL-D-23-00730.

Geboers, B., Scheltema, M. J., Blazevski, A., Katelaris, A., Doan, P., Ali, I., Agrawal, S., Barreto, D., Matthews, J., Haynes, A. M., Delprado, W., Shnier, R., Thompson, J. E., & Stricker, P. D. (2023). Median 4-year outcomes of salvage irreversible electroporation for localized radio-recurrent prostate cancer. BJU International. Advance online publication. https://doi.org/10.1111/bju.15948

Geboers, B., Scheltema, M. J., Jung, J., Bakker, J., Timmer, F. E. F., Cerutti, X., Katelaris, A., Doan, P., Gondoputro, W., Blazevski, A., Agrawal, S., Matthews, J., Haynes, A. M., Robertson, T., Thompson, J. E., Meijerink, M. R., Clark, S. J., de Gruijl, T. D., & Stricker, P. D. (2024). Irreversible electroporation of localised prostate cancer downregulates immune suppression and induces systemic anti-tumour T-cell activation - IRE-IMMUNO study. BJU International. Advance online publication. https://doi.org/10.1111/bju.16496

Geboers, B., Gondoputro, W., Thompson, J. E., Reesink, D. J., van Riel, L. A. M. J. G., Zhang, D., Blazevski, A., Doan, P., Agrawal, S., Matthews, J., Haynes, A. M., Liu, Z., Delprado, W., Shnier, R., de Reijke, T. M., Lawrentschuk, N., Stijns, P. E. F., Yaxley, J. W., Scheltema, M. J., & Stricker, P. D. (2022). Diagnostic accuracy of multiparametric magnetic resonance imaging to detect residual prostate cancer following irreversible electroporation—A multicenter validation study. European Urology Focus, 8(6), 1732–1739. https://doi.org/10.1016/j.euf.2022.04.010

Geboers, B., Meijer, D., Counter, W., Gianduzzo, T., Kwan, L., Yaxley, J., Roberts, M., Lawrencehuk, N., Katelaris, A., Doan, P., Agrawal, S., Scheltema, M. J., & Stricker, P. (2024). Prostate-specific membrane antigen positron emission tomography in addition to multiparametric magnetic resonance imaging and biopsies to select prostate cancer patients for focal therapy. BJU International, 133(Suppl 4), 14–22. https://doi.org/10.1111/bju.16207

Lantz, A., Nordlund, P., Falagario, U., Jäderling, F., Özbek, O., Clements, M., Discacciati, A., Grönberg, H., Eklund, M., Stricker, P., Emberton, M., Aly, M., & Nordström, T. (2023). Prostate Cancer IRE Study (PRIS): A Randomized Controlled Trial Comparing Focal Therapy to Radical Treatment in Localized Prostate Cancer. European Urology Open Science, 51, 89–94. https://doi.org/10.1016/j.euros.2023.03.003

Ong, S., Chen, K., Grummet, J., Yaxley, J., Scheltema, M. J., Stricker, P., Tay, K. J., & Lawrentschuk, N. (2022). Guidelines of guidelines: focal therapy for prostate cancer, is it time for consensus? BJU International. Advance online publication. https://doi.org/10.1111/bju.15883

Rodríguez-Sánchez, L., Emberton, M., de Reijke, T., Stricker, P., Miñana, B., Bianco, F., Escrig, J. L. D., Lantz, A., & Sanchez-Salas, R. (2023). Revisiting Delphi to create a basis for the future of focal therapy for prostate cancer. The World Journal of Men’s Health. Advance online publication. https://doi.org/10.5534/wjmh.230160

Scheltema, M. J., & Stricker, P. D. (2025). Prospective multicentre validation of focal irreversible electroporation as an attractive treatment option for localised intermediate-risk prostate cancer. European Urology. Advance online publication. https://doi.org/10.1016/j.eururo.2025.10.003

Scheltema, M. J., Katelaris, A., & Stricker, P. D. (2023). Salvage irreversible electroporation for radio-recurrent prostate cancer. Nature Reviews Urology, 20(6), 359–371. https://doi.org/10.1038/s41585-023-00750-1

Scheltema, M. J., Chang, J. I., Bohm, M., van den Bos, W., Blazevski, A., Gielchinsky, I., Kalsbeek, A. M. F., van Leeuwen, P. J., Nguyen, T. V., de Reijke, T. M., Siriwardana, A. R., Thompson, J. E., de la Rosette, J. J., & Stricker, P. D. (2018). Pair-matched patient-reported quality of life and early oncological control following focal irreversible electroporation versus robot-assisted radical prostatectomy. World Journal of Urology, 36(7), 1019–1025. https://doi.org/10.1007/s00345-018-2281-z

Scheltema, M. J., Chang, J. I., van den Bos, W., Gielchinsky, I., Nguyen, T. V., de Reijke, T. M., Siriwardana, A. R., Bohm, M., de la Rosette, J. J., & Stricker, P. D. (2018). Impact on genitourinary function and quality of life following focal irreversible electroporation of different prostate segments. Diagnostic and Interventional Radiology, 24(5), 268–275. https://doi.org/10.5152/dir.2018.17374

Scheltema, M. J., Geboers, B., Blazevski, A., Doan, P., Katelaris, A., Agrawal, S., Barreto, D., Shnier, R., Delprado, W., Thompson, J. E., & Stricker, P. D. (2022). Median 5-year outcomes of primary focal irreversible electroporation for localised prostate cancer. BJU International. Advance online publication. https://doi.org/10.1111/bju.15946

Scheltema, M. J., van den Bos, W., Siriwardana, A. R., Kalsbeek, A. M. F., Thompson, J. E., Ting, F., Bohm, M., Haynes, A. M., Shnier, R., Delprado, W., & Stricker, P. D. (2017). Feasibility and safety of focal irreversible electroporation as salvage treatment for localized radio-recurrent prostate cancer. BJU International, 120(S3), 51–58. https://doi.org/10.1111/bju.13991

Scheltema, M. J., O’Brien, T. J., van den Bos, W., de Bruin, D. M., Davalos, R. V., van den Geld, C. W. M., Laguna, M. P., Neal, R. E., Varkarakis, I. M., Skolarikos, A., Stricker, P. D., de Reijke, T. M., Arena, C. B., & de la Rosette, J. J. (2019). Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences. Therapeutic Advances in Urology, 11, 1756287219852305. https://doi.org/10.1177/1756287219852305

Storino Ramacciotti, L., Abreu, A. L., Crouzet, S., Macek, P., Miles, B. J., Horuz, R., Nunes-Carneiro, D., Stricker, P., Scionti, S., & Laguna, M. P. (2024). Salvage treatments after focal therapy for prostate cancer—a comprehensive review. Prostate Cancer and Prostatic Diseases. Advance online publication. https://doi.org/10.1038/s41391-024-00875-3

Ting, F., Tran, M., Böhm, M., Siriwardana, A., van Leeuwen, P. J., Haynes, A. M., Delprado, W., Shnier, R., & Stricker, P. D. (2015). Focal irreversible electroporation for prostate cancer: functional outcomes and short-term oncological control. Prostate Cancer and Prostatic Diseases, 19(1), 46–52. https://doi.org/10.1038/pcan.2015.47

Ting, F., van Leeuwen, P. J., & Stricker, P. D. (2016). Step-by-step technique for irreversible electroporation of focal prostate cancer: An instructional video guide. Journal of Vascular and Interventional Radiology, 27(4), 568–572. https://doi.org/10.1016/j.jvir.2016.01.003

Valerio, M., Stricker, P. D., Ahmed, H. U., Dickinson, L., Ponsky, L., Shnier, R., Allen, C., & Emberton, M. (2014). Initial assessment of safety and clinical feasibility of irreversible electroporation in the focal treatment of prostate cancer. Prostate Cancer and Prostatic Diseases, 17(4), 343–347. https://doi.org/10.1038/pcan.2014.33

van den Bos, W., Scheltema, M. J., Siriwardana, A. R., Kalsbeek, A. M. F., Thompson, J. E., Ting, F., Bohm, M., Haynes, A. M., Shnier, R., Delprado, W., & Stricker, P. D. (2018). Focal irreversible electroporation as primary treatment for localized prostate cancer. BJU International, 121(5), 716–724. https://doi.org/10.1111/bju.13983

van Riel, L. A. M. J. G., Geboers, B., Kabaktepe, E., Blazevski, A., Reesink, D. J., Stijns, P., Stricker, P. D., Casanova, J., Dominguez-Escrig, J. L., de Reijke, T. M., Scheltema, M. J., & Oddens, J. R. (2022). Outcomes of salvage radical prostatectomy after initial irreversible electroporation treatment for recurrent prostate cancer. BJU International, 130(2), 224–232. https://doi.org/10.1111/bju.15759

Williams, I. S. C., Katelaris, A., Geboers, B., Doan, P., Delprado, W., Scheltema, M. J., & Stricker, P. (2024). Transrectal ultrasound as real-time confirmation of adequate needle positioning during irreversible electroporation in focal therapy of prostate cancer. Videourology, 37(4), 1–2. https://doi.org/10.1089/vid.2023.0046

Zhang, K., Stricker, P., Löhr, M., Stehling, M., Suberville, M., Cussenot, O., Lunelli, L., Ng, C. F., Teoh, J., Laguna, P., & de la Rosette, J. (2024). A multi-center international study to evaluate the safety, functional and oncological outcomes of irreversible electroporation for the ablation of prostate cancer. Prostate Cancer and Prostatic Diseases. Advance online publication. https://doi.org/10.1038/s41391-023-00783-y

Presentations

Jung J. February 2024. Irreversible electroporation of intermediate risk prostate cancer mitigates immune suppression and induces systemic antitumor T cell activation
ASANZ Meeting Adelaide

Geboers B. June 2024. Irreversible Electroporation - Cytoreduction and Immunomodulation in Oncology
PhD Dissertation Vrije University Amsterdam, the Netherlands

Geboers B. January 2023. Rising Star Session: Additional Diagnostic Accuracy of PSMA-PET to select prostate cancer patients for hemi-ablative focal therapy
SVHA research symposium, Sydney, Australia

Geboers B. July 2022. Diagnostic Accuracy of Multiparametric MRI to detect residual prostate cancer following IRE
EAU, Amsterdam, the Netherlands