Imaging


Ongoing Projects

Primary 2: Prospective multi-centre randomised trial of the additive diagnostic value of PSMA PET in men with negative/equivocal MRI in the diagnosis of significant prostate cancer (PSMA-PET imaging)
CLARIFY: Positron Emission Tomography using 64Cu-SAR-bisPSMA in participants with high-risk prostate cancer prior to radical prostatectomy: A prospective, single-arm, multi-center, blinded-review, Phase 3 diagnostic performance study (Imaging)

Our Publications on Imaging

Algohary, A., Shiradkar, R., Pahwa, S., Purysko, A., Verma, S., Moses, D., … Madabhushi, A. (2020). Combination of Peri-Tumoral and Intra-Tumoral Radiomic Features on Bi-Parametric MRI Accurately Stratifies Prostate Cancer Risk: A Multi-Site Study. Cancers , 12 (8). https://doi.org/10.3390/cancers12082200
Algohary, A., Viswanath, S., Shiradkar, R., Ghose, S., Pahwa, S., Moses, D., … Madabhushi, A. (2018). Radiomic features on MRI enable risk categorization of prostate cancer patients on active surveillance: Preliminary findings. Journal of Magnetic Resonance Imaging : JMRI . https://doi.org/10.1002/jmri.25983
Emmett, L., Buteau, J., Papa, N., Moon, D., Thompson, J., Roberts, M. J., … Stricker, P. (2021). The Additive Diagnostic Value of Prostate-specific Membrane Antigen Positron Emission Tomography Computed Tomography to Multiparametric Magnetic Resonance Imaging Triage in the Diagnosis of Prostate Cancer (PRIMARY): A Prospective Multicentre Study. European Urology , 80 (6), 682–689. https://doi.org/10.1016/j.eururo.2021.08.002
Emmett, L., Tang, R., Nandurkar, R., Hruby, G., Roach, P., Watts, J. A., … Science, M. (2019). 3 year freedom from progression following 68 GaPSMA PET CT triaged management in men with biochemical recurrence post radical prostatectomy . Results of a prospective multi‐center. Journal of Nuclear Medicine , epub ahead . https://doi.org/10.2967/jnumed.119.235028
Emmett, L., Van Leeuwen, P., Nandurkar, R., Scheltema, M. J., Cusick, T., Hruby, G., … Stricker, P. (2017). Treatment outcomes from 68 GaPSMA PET CT informed salvage radiation treatment in men with rising PSA following radical prostatectomy: Prognostic value of a negative PSMA PET. Journal of Nuclear Medicine , jnumed.117.196683. https://doi.org/10.2967/jnumed.117.196683
Huits, T. H., Luiting, H. B., van der Poel, H. G., Nandurkar, R., Donswijk, M., Schaake, E., … van Leeuwen, P. J. (2020). Distribution of prostate cancer recurrences on gallium-68 prostate-specific membrane antigen ((68) Ga-PSMA) positron-emission/computed tomography after radical prostatectomy with pathological node-positive extended lymph node dissection. BJU International , 125 (6), 876–883. https://doi.org/10.1111/bju.15052
Morigi, J. J., Stricker, P. D., van Leeuwen, P. J., Tang, R., Ho, B., Nguyen, Q., … Emmett, L. (2015). Prospective Comparison of 18F-Fluoromethylcholine Versus 68Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Authored Therapy. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine , 56 (8), 1185–1190. https://doi.org/10.2967/jnumed.115.160382
Nandurkar, R., van Leeuwen, P., Stricker, P., Woo, H., Kooner, R., Yuen, C., … Emmett, L. (2019). (68)Ga-HBEDD PSMA-11 PET/CT staging prior to radical prostatectomy in prostate cancer patients: Diagnostic and predictive value for the biochemical response to surgery. The British Journal of Radiology , 92 (1095), 20180667. https://doi.org/10.1259/bjr.20180667
Penzias, G., Singanamalli, A., Elliott, R., Gollamudi, J., Shih, N., Feldman, M., … Madabhushi, A. (2018). Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings. PloS One , 13 (8), e0200730. https://doi.org/10.1371/journal.pone.0200730
Roach, P. J., Francis, R., Emmett, L., Hsiao, E., Kneebone, A., Hruby, G., … Scott, A. M. (2018). The Impact of (68)Ga-PSMA PET/CT on Management Intent in Prostate Cancer: Results of an Australian Prospective Multicenter Study. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine , 59 (1), 82–88. https://doi.org/10.2967/jnumed.117.197160
Rusu, M., Purysko, A. S., Verma, S., Kiechle, J., Gollamudi, J., Ghose, S., … Madabhushi, A. (2017). Computational imaging reveals shape differences between normal and malignant prostates on MRI. Scientific Reports , 7 , 41261. https://doi.org/10.1038/srep41261
Thompson, J. E., Van Leeuwen, P. J., Moses, D., Shnier, R., Brenner, P., Delprado, W., … Stricker, P. D. (2016). The diagnostic performance of multiparametric magnetic resonance imaging to detect significant prostate cancer. Journal of Urology , 195 (5), 1428–1435. https://doi.org/10.1016/j.juro.2015.10.140
Thompson, James E., Moses, D., Shnier, R., Brenner, P., Delprado, W., Ponsky, L., … Stricker, P. D. (2014). Multiparametric magnetic resonance imaging guided diagnostic biopsy detects significant prostate cancer and could reduce unnecessary biopsies and over detection: A prospective study. Journal of Urology , 192 (1), 67–74. https://doi.org/10.1016/j.juro.2014.01.014
Thompson, James E, & Stricker, P. D. (2017). Diagnostic accuracy of multi-parametric MRI and transrectal ultrasound-guided biopsy in prostate cancer. Lancet (London, England) , 389 (10071), 767–768. https://doi.org/10.1016/S0140-6736(17)30121-6
Tran, M., Thompson, J., Böhm, M., Pulbrook, M., Moses, D., Shnier, R., … Stricker, P. D. (2016). Combination of multiparametric MRI and transperineal template-guided mapping biopsy of the prostate to identify candidates for hemi-ablative focal therapy. BJU International , 117 (1), 48–54. https://doi.org/10.1111/bju.13090
van Leeuwen, P. J., Donswijk, M., Nandurkar, R., Stricker, P., Ho, B., Heijmink, S., … Emmett, L. (2019). Gallium-68-prostate-specific membrane antigen ((68) Ga-PSMA) positron emission tomography (PET)/computed tomography (CT) predicts complete biochemical response from radical prostatectomy and lymph node dissection in intermediate- and high-risk prostate c. BJU International , 124 (1), 62–68. https://doi.org/10.1111/bju.14506
van Leeuwen, P. J., Emmett, L., Ho, B., Delprado, W., Ting, F., Nguyen, Q., & Stricker, P. D. (2017). Prospective evaluation of 68Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer. BJU International , 119 (2), 209–215. https://doi.org/10.1111/bju.13540
van Leeuwen, P. J., Hayen, A., Thompson, J. E., Moses, D., Shnier, R., Böhm, M., … Stricker, P. D. (2017). A multiparametric magnetic resonance imaging-based risk model to determine the risk of significant prostate cancer prior to biopsy. BJU International , 120 (6), 774–781. https://doi.org/10.1111/bju.13814
van Leeuwen, P. J., Stricker, P., Hruby, G., Kneebone, A., Ting, F., Thompson, B., … Emmett, L. (2016). (68) Ga-PSMA has a high detection rate of prostate cancer recurrence outside the prostatic fossa in patients being considered for salvage radiation treatment. BJU International , 117 (5), 732–739. https://doi.org/10.1111/bju.13397